POSTINOR 1 TAB 1.5MG 1

Postinor-1 is an emergency contraceptive only. Postinor-1 is not intended as a regular method of contraception. It is used to prevent pregnancy when taken within 72 hours of unprotected intercourse. It is estimated that Postinor-1 will prevent 85% of expected pregnancies.

The sooner that you take Postinor-1 after unprotected intercourse, the more likely it is that the medication will work. Postinor-1 is most effective if taken within 72 hours of unprotected intercourse. But remember that the sooner you take it, the more likely it will prevent pregnancy.

Postinor-1 will not prevent you from catching sexually transmitted diseases. Ask your doctor or pharmacist if you have any questions about why you are taking Postinor-1.

PHARMACKINETICS
Orally:

– Absorption: after a dose of 1.5 mg, it is absorbed rapidly (tmax 2 h) and almost completely (near 100% bioavailability). The cmax is 18.5 ng / ml.

Food effect: they do not seem to affect significantly.

– Distribution: high plasma protein binding (> 97.5%), especially sex hormone binding globulin (65%) and albumin. The Vd is 1.8 l / kg. It is excreted in small amounts in breast milk (0.1% of the breast dose).

– Metabolism: it is extensively metabolized in the liver by the usual steroid routes, by hydroxylation by CYP3A4. Several metabolites that are subsequently glucuronated have been described. There are no active metabolites.

Enzyme inducing / inhibiting ability: does not appear to have a significant effect.

– Excretion: in urine (45%) and feces (32%), mainly as glucuronated metabolites. The CLt is 7.7 +/- 2.7 L / h, while the t1 / 2 is 26 h.

Pharmacokinetics in special situations:

– Other situations: there are no specific data in girls, elderly women or patients with renal or hepatic impairment.